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| Tom Holland to reprise his role as Spider-Man in the Venom sequel |
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| Tom Hardy to reprise his role as the lethal protector himself |
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| Woody Harrelson to reign as Carnage |
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| Michelle Williams to return as Anne Weying |
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| Reid Scott to come back as Dan |
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| Michelle Rodriguez to play Donna Diego/Scream |
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| Ramon Rodriguez to join in as Lasher |
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| Jesicca Camecho from the Flash to play Agony |
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| Scott Deckert to reprise his role as Eddie's noisy neighbor Ziggy |
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| John Favreau to join in as Happy Hogan |
